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New roles for the external globus pallidus in basal ganglia circuits and behavior.

Identifieur interne : 000234 ( France/Analysis ); précédent : 000233; suivant : 000235

New roles for the external globus pallidus in basal ganglia circuits and behavior.

Auteurs : Aryn H. Gittis [États-Unis] ; Joshua D. Berke [États-Unis] ; Mark D. Bevan [États-Unis] ; C Savio Chan [États-Unis] ; Nicolas Mallet [France] ; Michelle M. Morrow ; Robert Schmidt [Allemagne]

Source :

RBID : pubmed:25392486

Descripteurs français

English descriptors

Abstract

The development of methodology to identify specific cell populations and circuits within the basal ganglia is rapidly transforming our ability to understand the function of this complex circuit. This mini-symposium highlights recent advances in delineating the organization and function of neural circuits in the external segment of the globus pallidus (GPe). Although long considered a homogeneous structure in the motor-suppressing "indirect-pathway," the GPe consists of a number of distinct cell types and anatomical subdomains that contribute differentially to both motor and nonmotor features of behavior. Here, we integrate recent studies using techniques, such as viral tracing, transgenic mice, electrophysiology, and behavioral approaches, to create a revised framework for understanding how the GPe relates to behavior in both health and disease.

DOI: 10.1523/JNEUROSCI.3252-14.2014
PubMed: 25392486


Affiliations:


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pubmed:25392486

Le document en format XML

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